What Causes Neutrophilia?

Removal Of The Spleen

An individual who has undergone removal of their spleen may develop neutrophilia as a complication of their operation. The spleen and liver are capable of producing certain blood cells when the bone marrow is not making enough. At the same time, the spleen is a key component in the process of neutrophil removal and destruction of dead and dying neutrophils from the body. There are only three tissues in the body that can perform neutrophil clearance, including the spleen, liver, and bone marrow. All three of these contribute to the neutrophil clearance process equally in most healthy individuals. However, some individuals have had to have their spleen removed due to several different conditions and diseases. Without the spleen, the liver and bone marrow are left to perform the job of clearing out neutrophils marked for apoptosis and destruction. The removal of the spleen requires at least a minimally invasive procedure that results in post-operation inflammation. This process causes an increase in the production of neutrophils, with only two-thirds of the healthy neutrophil clearance functionality left. Neutrophilia is often the result of this mechanism.

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