Causes, Risk Factors, And Complications Of Primary Biliary Cholangitis

Osteoporosis

Osteoporosis is a condition characterized by microarchitectural malformation, low bone mass, and structural weakness in the bones. There are several ways osteoporosis can develop in a patient who has impaired liver function due to primary biliary cholangitis. Bone maintains its strength and integrity through a complex balance of breakdown and rebuilding processes in an individual's body. This balance is regulated by hormones and other mechanisms that depend on an adequate supply of calcium and vitamin D, a balanced hormonal environment, the right amount of mechanical stress, and good nutrition. When any of these factors are altered abnormally, the delicate balance of bone breakdown and regeneration is interrupted. Primary biliary cholangitis can cause problems with the absorption and or metabolism of calcium and vitamin D, disrupt healthy levels of certain hormones, and interfere with an individual's utilization of nutrients that come from the food they eat. When this condition produces an alteration in the bone breakdown-regeneration balance, the patient can develop osteoporosis.

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