Causes And Risk Factors Of Trimethylaminuria

Kidney Disease

Although trimethylaminuria is a disorder caused by a liver enzyme deficiency, kidney disease can definitely contribute to and worsen the malodorous symptoms of trimethylaminuria. The kidneys are responsible for collecting, concentrating and eliminating body wastes, particularly urea. When the kidneys don't function correctly, a serious condition called uremia can occur. Uremia means there is a dangerous amount of urea in an individual's bloodstream. Urea is toxic. Healthy kidneys keep this substance cleared from the body. The kidneys are also responsible for the elimination of other compounds too. One is the trimethylamine produced by a patient with trimethylaminuria. When there is any delay in its elimination by the kidneys, such as in the case of kidney disease, there will likely be an increase in odor from the TMA. Uremia itself can also produce a certain type of unpleasant body odor.

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