Common Symptoms Of Mastocytosis

Facial Flushing

Facial flushing is a symptom of mastocytosis that occurs at some point in the majority of individuals affected by the condition. Facial flushing in systemic mastocytosis has been described as a bright red coloring of the face with sensations of itchiness and burning. This flushing often occurs alongside gastrointestinal symptoms that are also the result of systemic mastocytosis. Facial flushing in affected individuals tends to occur abruptly and quickly. Reddish-brown bumps have occurred as a feature of the facial flushing. Mastocytosis causes increased immune sensitivity to certain antigens and triggers that induce a release of histamine by excess mast cells in the affected individual's facial tissues. This produces a type of episode or allergic-like attack on the face, where histamine and other immune components cause a significant dilation of the blood vessels in the skin. The vessel dilation, histamine release, and congregation of other immune system components in the area are all implicated in giving the face a reddish appearance with burning and itching sensations.

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