Common Symptoms Of Mastocytosis

Enlarged Spleen Or Liver

The liver is a large organ that helps clear toxins and waste products from the blood. The spleen is a lymphatic system organ that also serves to remove dead cell parts and wastes from the blood so they can be excreted in the stool and urine. Because mast cells are large cells, they can leave less room for components of the blood to circulate properly. This mechanism can produce portal hypertension, or an increased blood pressure level in the veins that make up the portal venous system. The portal venous system is the network of vessels that allow blood to flow throughout the liver. The accumulated mast cells in the blood can accumulate in the portal venous system as the liver tries to remove them from the blood. The spleen also becomes enlarged when it takes on a buildup of mast cells it is also trying to filter from the blood. Inflammation that occurs in the liver can cause the swelling of the spleen and vice versa because of their proximity to each other.

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