Symptoms Of Primary Biliary Cholangitis

Musculoskeletal Pain

Musculoskeletal pain is a symptom of primary biliary cholangitis that occurs in the later stages of the disease. Musculoskeletal pain is pain experienced in the joints, bones, or muscles. This is caused by vitamin deficiencies, which can lead to osteoporosis. The lack of bile in the liver affects the body's ability to absorb fats and fat-soluble vitamins important for bone health. Vitamin D specifically aids in bone, joint, and muscle health, and helps maintain bone density throughout the body. The liver is in charge of making vital nutrients, so when the liver isn't working properly, the body is deficient. In the late stages of primary biliary cholangitis, bone loss and bone fractures can occur, which can be debilitating and extremely painful. This symptom can be severe and should receive medical attention immediately.

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Jaundice

Jaundice, the yellowing of the skin and eyes, can be a symptom of primary biliary cholangitis in the end-stage of the disease and is a critical condition. This symptom is a way that the body communicates an organ isn't functioning properly. Jaundice is caused when the body breaks down excess dead red blood cells in the liver, which creates bilirubin, the yellow pigment. This occurs because the liver is not excreting the bile and is backed up in the liver. This symptom is a serious symptom and affected individuals should receive medical attention immediately.

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