How To Effectively Treat Meralgia Paresthetica

Tricyclic Antidepressants

Tricyclic antidepressants have the potential to help relieve pain in many medical conditions, including meralgia paresthetica. Different medications have slightly different side effects, but some typical side effects include constipation, dry mouth, and drowsiness. These medications affect the levels of neurotransmitters in the body, which are created by nerves to help send messages to other nerves throughout the body. A tricyclic antidepressant increases the levels of serotonin and norepinephrine in the body. In addition, they block acetylcholine, an additional neurotransmitter. Acetylcholine causes the contraction of muscles and allows the nerves to send pain signals. By blocking and reducing the amount of acetylcholine in the body, the nerves fail to send as many pain signals as usual. Doctors may pair one of these antidepressants with an anticonvulsant medication to further reduce pain.