Warning Signs Of Amyloidosis

Numbness And Tingling In The Hands And Feet

Numbness and tingling in the hands or feet can be an indication an individual has amyloidosis. Numbness, tingling, burning sensation, and a lack of feeling can manifest in the toes, soles of the feet, fingers, and hands. Temperature sensitivity may also become decreased in the hands and feet. These sensations are the result of amyloidosis precipitated neuropathies of the peripheral nerves, sensory nerves, and sometimes the autonomic nerves. Approximately twenty percent of individuals affected by amyloidosis experience some form of peripheral neuropathy, while around fifteen percent experience autonomic neuropathy. Cardiac involvement in autonomic neuropathies can cause symptomatic postural hypotension that results in the shortage of oxygen delivery to the hands and feet, which may induce numbness and tingling sensations. Amyloidosis patients can develop carpal tunnel syndrome due to amyloid deposits in the rigid carpal tunnel, causing the main nerve that feeds the hand to become compressed. The compressed nerve can cause numbness and tingling feelings in the fingers and thumb.