Warning Signs Of Progressive Multifocal Leukoencephalopathy

Coordination Problems

Coordination problems can present with patients that have progressive multifocal leukoencephalopathy because of several different reasons. The difficulty most often occurs as a result of PML attacking the cerebellum, which is in the lower back part of the brain. The cerebellum has the responsibility of keeping a person balanced, facilitating their posture, and coordinating most muscle movements. In addition, problems with coordination can manifest when PML attacks the motor strip located in the frontal lobe of the cerebrum. The parietal lobe also is responsible for motor signals and damage to that component may cause poor coordination. When PML attacks the portion of the cerebrum responsible for fine movement control, the individual can experience coordination problems in the hands, feet, and toes. Lastly, the basal ganglia is another part of the brain that coordinates the body's fine movements that can also be affected by the damage this condition causes. The areas of the brain affected by PML lesions often have permanent damage because central nervous system cells do not re-myelinate or form new white matter.

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