What Is Duloxetine (Cymbalta)?

Potential Medication Interactions

Duloxetine seems to have many potential medication interactions. Due to this, patients may want to consider writing a list of their current medications. Doctors may be able to use this list to help avoid these potential medication interactions. It appears that patients are not able to take duloxetine with any medications that are considered MAOIs. However, it also seems that they will need to wait approximately fourteen days after stopping MAOIs if they want to switch to this medication.

Patients will also likely need to avoid taking other medicines that impact their serotonin. Taking more than one of these medications may increase their risk of serotonin syndrome significantly. Thus, they may want to make a point of mentioning any other antidepressants they take to their doctor. Other medicines that may interact with duloxetine seem to include migraine medications, heart medication, diuretics, and anti-inflammatories. Certain ADHD medications may also cause significant interactions with duloxetine. Some herbal supplements can also create issues, so patients may want to include these on their list. An example of a herbal supplement that this may apply to is St. John's Wort.