What Is Percocet?

Potential Medication Interactions

Percocet has potential medication interactions with more than one hundred other medicines. Severe interactions could occur if Percocet is taken with other opioid analgesics or with naltrexone, and serious interactions also exist between Percocet and some types of CYP3A4 inhibitors. Due to the risk of potential interactions, patients should not take Percocet with sodium fusidate, sodium oxybate, or other medications that contain acetaminophen. Since Percocet causes respiratory depression, serious breathing issues could occur if it is taken in combination with other medicines that also depress the respiratory system. Moderate drug interactions could occur if patients take Percocet with muscle relaxants, sleeping aids, tranquilizers, benzodiazepines, phenothiazine, hydrocodone, or gabapentinoids.

Moderate interactions could also occur if Percocet is used with certain types of anticoagulants or medicines that carry a risk of hyponatremia, and Percocet should not be used with primidone, cimetidine, isoniazid, or nalbuphine. Since Percocet has the potential to interact with so many different types of medicine, patients must inform their healthcare team about all prescription, non-prescription, and natural or herbal medicines they currently take. Doctors need this information to determine if it is safe for the patient to use Percocet and if the benefits of the medication outweigh the risks of potential drug interactions. Pharmacists should also check the patient's medication list for potential drug interactions before dispensing Percocet.