Guide To The Types Of Multiple Sclerosis

Secondary-Progressive Multiple Sclerosis

Secondary-progressive multiple sclerosis (SPMS) is a form of multiple sclerosis characterized by a relapsing and remitting disease course. The secondary progression course of multiple sclerosis is defined by an accumulation of the patient's disability over time or progressive worsening of the individual's neurological function. The terms active, not active, with progression, and without progression can be used to describe the state of a patient's SPMS. When there is evidence of new MRI activity and or a relapse of symptoms, it is considered to be active SPMS. When there is evidence the disease is becoming worse on an objective assessment of change over time, it is described as SPMS with progression. The majority of the individuals who are diagnosed with the RRMS variation will ultimately progress to a secondary progression course. While relapsing-remitting multiple sclerosis is caused by bouts of inflammation, an individual's multiple sclerosis will gradually alter over time from the RRMS inflammation precipitated episodes to the more steadily worsening phase of secondary-progressive multiple sclerosis characterized by nerve loss or damage.

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